Besides a genetic predisposition, there are a variety of physical indicators, such as foot deformities, fatigue, muscle weakness, and hammertoes that lead a patient to suspect that he or she may have Charcot-Marie-Tooth disease (CMT). Many forms of CMT can be diagnosed through a simple DNA blood test analysis. This is by far the least invasive way to learn this important information. CMT can also be diagnosed with an Electromyogram or EMG. This is a two-part test and can be slightly uncomfortable.