Sjögren’s syndrome is an autoimmune disorder. The body’s immune system attacks glands that secrete fluid, such as the tear and saliva glands. The effects of Sjögren’s syndrome can be widespread. Certain glands become inflamed, which reduces the production of tears and saliva, causing the main symptoms of Sjögren’s syndrome, which are dry eyes and dry mouth. In women (who are most commonly affected), the glands that keep the vagina moist can also be affected, leading to vaginal dryness.