Mouth cancer and mouth sores are distinctive in their symptoms. However, as mentioned earlier, new or persistent sores require checking. There are some fundamental differences between mouth sores and what might be cancer: Mouth sores are often painful whereas mouth cancer is not; Mouth sores will clear up in about 2 weeks, whereas mouth cancer will not go away and will often spread; Mouth cancer patches may be rough, hard, and not easy to scrape off; Mouth cancer is often a mix of red and white areas or large white areas that appear on the tongue, the back of the mouth, the gums, or on the cheeks and Mouth cancer is often linked to heavy drinking or tobacco use.