Mouth sores are common ailments that affect many people at some point in their lives. These sores can appear on any of the soft tissues of your mouth, including your lips, cheeks, gums, tongue, and floor and roof of your mouth. You can even develop mouth sores on your esophagus, the tube leading to your stomach. Mouth sores, which include canker sores, are usually a minor irritation and last only a week or two. In some cases, however, they can indicate mouth cancer or an infection from a virus, such as herpes simplex