The medical and psychological factors that can also hamper sexual desire, include: painful intercourse; erectile dysfunction (impotence); delayed ejaculation (inability to ejaculate during intercourse); negative thinking patterns (anger, dependency, fear of intimacy, or feelings of rejection); pregnancy and breast-feeding; mental health problems (depression, anxiety, low self-esteem); stress; use/overuse of alcohol and street drugs; chronic illness; pain and fatigue; side effects of medicines (especially antidepressants and anti-seizure drugs); hormonal changes; low testosterone (in both women and men) and menopause.