Common symptoms of hemophilia include: Bleeding into the joints. This can cause swelling and pain or tightness in the joints; it often affects the knees, elbows, and ankles; Bleeding into the skin (which is bruising) or muscle and soft tissue causing a build-up of blood in the area (called a hematoma); Bleeding of the mouth and gums, and bleeding that is hard to stop after losing a tooth; Bleeding after circumcision (surgery performed on male babies to remove the hood of skin, called the foreskin, covering the head of the penis); Bleeding after having shots, such as vaccinations; Bleeding in the head of an infant after a difficult delivery; Blood in the urine or stool and Frequent and hard-to-stop nosebleeds.