Treatment for pleurisy depends on the underlying cause. For example, pleurisy caused by a viral infection will often resolve itself without treatment. However, pleurisy caused by a bacterial infection is usually treated with antibiotics and people who are frail or already in poor health may be admitted to hospital. Non-steroidal anti-inflammatory drugs are often used to relieve the chest pain associated with pleurisy. If excess fluid builds up between the pleural layers, it may be necessary to drain the fluid to prevent breathing difficulties. Pleurisy is inflammation of the pleura. It’s usually caused by another condition, such as an infection, but sometimes no cause can be identified. The pleura are two thin sheets of tissue that separate the lungs and ribcage. One is attached to the ribcage and the other is attached to the lungs. Between the pleural sheets is a thin layer of liquid that lubricates the pleura, helping to reduce friction when you breathe in and out. When there’s inflammation, the surfaces of the two layers can become rough and the fluid can become sticky. This can cause the layers to rub together, resulting in pain and discomfort.