Japanese encephalitis (JE) is a potentially severe disease, caused by a virus spread by infected mosquitoes and the JE virus is one of a group of mosquito-transmitted viruses that can cause inflammation of the brain (encephalitis). JE occurs in rural or agricultural areas, often associated with rice farming. In temperate areas, transmission is seasonal, and human disease usually peaks in the summer and fall. In the subtropics and tropics, transmission can occur year-round, often with a peak during the rainy season. It takes 5 to 15 days after the bite of an infected mosquito to develop symptoms.