With all types of Charcot-Marie-Tooth disease (CMT), the nerve signals are disrupted or weakened, resulting in severe muscle wasting and pain. Often, the muscle wasting happens unevenly, which causes deformity as opposing muscles atrophy at different rates. In many cases, the symptoms are mild and an altered gait can be corrected with a properly fitting orthodic. In more severe cases, people with CMT must wear braces or use a wheelchair to get around. In the worst cases, CMT can impair breathing and cause death.