Whipple’s disease prevents your body from properly absorbing nutrients. Because of this, it affects many different parts of the body and is associated with a variety of symptoms. In advanced stages of the disease, the infection may spread from the intestines to other organs such as the: heart; lungs; brain; joints; eyes. The most common signs and symptoms of Whipple’s disease include: chronic joint pain; chronic diarrhea that can be bloody; significant weight loss; stomach pain and bloating; decreased vision and eye pain; fever; fatigue; anemia or low red blood cell count. The following signs and symptoms don’t occur as frequently but can indicate that the condition is getting worse: skin discoloration; inflamed lymph nodes; a chronic cough; pain in the chest; pericarditis or swelling of the sac surrounding the heart; heart failure; a heart murmur; poor vision; dementia; numbness; insomnia; muscle weakness; tics; trouble walking and poor memory.