If the patches do not clear up on their own, they may be removed by a doctor, often with a scalpel. Follow-up appointments are recommended frequently for ongoing cases and typically yearly for resolved cases. Leukoplakia recurrences are common. When associated with conditions like HIV, antiviral medications may be prescribed. If pre-cancerous or cancerous cells are discovered, additional testing measures will be necessary to determine the extent of the condition. Treatment is based on the type of cells present.